Abnormal Resting-State Connectivity in a Substantia Nigra-Related Striato-Thalamo-Cortical Network in a Large Sample of First-Episode Drug-Naïve Patients With Schizophrenia.

doi:10.1093/schbul/sbx067

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Title:	Abnormal Resting-State Connectivity in a Substantia Nigra-Related Striato-Thalamo-Cortical Network in a Large Sample of First-Episode Drug-Naïve Patients With Schizophrenia.
Authors:	藍亭 Martino, Matteo Magioncalda, Paola Yu, Hua Li, Xiaojing Wang, Qiang Meng, Yajing Deng, Wei Li, Yinfei Li, Mingli Ma, Xiaohong Lane, Timothy Duncan, Niall W. Northoff, Georg Li, Tao
Contributors:	心理學系
Keywords:	schizophrenia:substantia nigra:resting-state, fMRI:functional connectivity:slow frequency bands:neural synchronization
Date:	2018-02
Issue Date:	2018-01-15 11:39:34 (UTC+8)
Abstract:	Objective: The dopamine hypothesis is one of the most influential theories of the neurobiological background of schizophrenia (SCZ). However, direct evidence for abnormal dopamine-related subcortical-cortical circuitry disconnectivity is still lacking. The aim of this study was therefore to test dopamine-related substantia nigra (SN)-based striato-thalamo-cortical resting-state functional connectivity (FC) in SCZ. Method: Based on our a priori hypothesis, we analyzed a large sample resting-state functional magnetic resonance imaging (fMRI) dataset from first-episode drug-naïve SCZ patients (n = 112) and healthy controls (n = 82) using the SN as the seed region for an investigation of striato-thalamo-cortical FC. This was done in the standard band of slow frequency oscillations and then in its subfrequency bands (Slow4 and Slow5). Results: The analysis showed in SCZ: (1) reciprocal functional hypo-connectivity between SN and striatum, with differential patterns for Slow5 and Slow4; (2) functional hypo-connectivity between striatum and thalamus, as well as functional hyper-connectivity between thalamus and sensorimotor cortical areas, specifically in Slow4; (3) correlation of thalamo-sensorimotor functional hyper-connectivity with psychopathological symptoms. Conclusions: We demonstrate abnormal dopamine-related SN-based striato-thalamo-cortical FC in slow frequency oscillations in first-episode drug-naive SCZ. This suggests that altered dopaminergic function in the SN leads to abnormal neuronal synchronization (as indexed by FC) within subcortical-cortical circuitry, complementing the dopamine hypothesis in SCZ on the regional level of resting-state activity.
Relation:	Schizophrenia Bulletin, Volume 44, Issue 2, Pages 419–431
Data Type:	article
DOI:	http://dx.doi.org/10.1093/schbul/sbx067

DCField	Value	Language
dc.contributor (Contributor)	心理學系	zh_TW
dc.creator (Authors)	藍亭	zh_TW
dc.creator (Authors)	Martino, Matteo	en_US
dc.creator (Authors)	Magioncalda, Paola	en_US
dc.creator (Authors)	Yu, Hua	en_US
dc.creator (Authors)	Li, Xiaojing	en_US
dc.creator (Authors)	Wang, Qiang	en_US
dc.creator (Authors)	Meng, Yajing	en_US
dc.creator (Authors)	Deng, Wei	en_US
dc.creator (Authors)	Li, Yinfei	en_US
dc.creator (Authors)	Li, Mingli	en_US
dc.creator (Authors)	Ma, Xiaohong	en_US
dc.creator (Authors)	Lane, Timothy	en_US
dc.creator (Authors)	Duncan, Niall W.	en_US
dc.creator (Authors)	Northoff, Georg	en_US
dc.creator (Authors)	Li, Tao	en_US
dc.date (Date)	2018-02	-
dc.date.accessioned	2018-01-15 11:39:34 (UTC+8)	-
dc.date.available	2018-01-15 11:39:34 (UTC+8)	-
dc.date.issued (Issue Date)	2018-01-15 11:39:34 (UTC+8)	-
dc.identifier.uri (URI)	http://nccur.lib.nccu.edu.tw/handle/140.119/115565	-
dc.description.abstract (Abstract)	Objective: The dopamine hypothesis is one of the most influential theories of the neurobiological background of schizophrenia (SCZ). However, direct evidence for abnormal dopamine-related subcortical-cortical circuitry disconnectivity is still lacking. The aim of this study was therefore to test dopamine-related substantia nigra (SN)-based striato-thalamo-cortical resting-state functional connectivity (FC) in SCZ. Method: Based on our a priori hypothesis, we analyzed a large sample resting-state functional magnetic resonance imaging (fMRI) dataset from first-episode drug-naïve SCZ patients (n = 112) and healthy controls (n = 82) using the SN as the seed region for an investigation of striato-thalamo-cortical FC. This was done in the standard band of slow frequency oscillations and then in its subfrequency bands (Slow4 and Slow5). Results: The analysis showed in SCZ: (1) reciprocal functional hypo-connectivity between SN and striatum, with differential patterns for Slow5 and Slow4; (2) functional hypo-connectivity between striatum and thalamus, as well as functional hyper-connectivity between thalamus and sensorimotor cortical areas, specifically in Slow4; (3) correlation of thalamo-sensorimotor functional hyper-connectivity with psychopathological symptoms. Conclusions: We demonstrate abnormal dopamine-related SN-based striato-thalamo-cortical FC in slow frequency oscillations in first-episode drug-naive SCZ. This suggests that altered dopaminergic function in the SN leads to abnormal neuronal synchronization (as indexed by FC) within subcortical-cortical circuitry, complementing the dopamine hypothesis in SCZ on the regional level of resting-state activity.	en_US
dc.format.extent	103 bytes	-
dc.format.mimetype	text/html	-
dc.relation (Relation)	Schizophrenia Bulletin, Volume 44, Issue 2, Pages 419–431	en_US
dc.subject (Keywords)	schizophrenia:substantia nigra:resting-state, fMRI:functional connectivity:slow frequency bands:neural synchronization	en_US
dc.title (Title)	Abnormal Resting-State Connectivity in a Substantia Nigra-Related Striato-Thalamo-Cortical Network in a Large Sample of First-Episode Drug-Naïve Patients With Schizophrenia.	en_US
dc.type (Data Type)	article	-
dc.identifier.doi (DOI)	10.1093/schbul/sbx067	-
dc.doi.uri	http://dx.doi.org/10.1093/schbul/sbx067	-

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