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| Field |
Value |
| Title: | Strong Circadian Rhythms in the Choroid Plexus: Implications for Sleep-Independent Brain Metabolite Clearance |
| Authors: | Myung, Jihwan;Wu, Dean;Simonneaux, Valérie;Lane, Timothy Joseph
藍亭
Lane, Timothy Joseph |
| Contributors: | 心腦中心 |
| Keywords: | Choroid plexus; circadian clock; metabolite clearance; neurodegenerative disease |
| Date: | 2018 |
| Issue Date: | 2018-09-11 18:34:10 (UTC+8) |
| Abstract: | Cerebrospinal fluid (CSF) is a fluidic part of the brain’s microenvironment that isolates the brain from the rest of the body. CSF dilutes metabolites from neuronal activities and removes them from the brain. Its production and resorption are regulated dynamically and are central to maintaining brain homeostasis. We discovered that the major CSF source, the choroid plexus (CP), harbors the brain’s strongest circadian clock. Here, we consider some implications of the CP circadian clock for metabolite clearance in the brain. If the circadian clock contributes to timed production of the CSF, its synchronization with sleep timing can maximize clearance efficiency and help prevent neurodegenerative diseases such as Alzheimer’s disease. |
| Relation: | Journal of Experimental Neuroscience, Vol.12 |
| Data Type: | article |
| DOI: | https://doi.org/10.1177/1179069518783762 |
| DCField |
Value |
Language |
| dc.contributor (Contributor) | 心腦中心 | |
| dc.creator (Authors) | Myung, Jihwan;Wu, Dean;Simonneaux, Valérie;Lane, Timothy Joseph | en_US |
| dc.creator (Authors) | 藍亭 | zh_TW |
| dc.creator (Authors) | Lane, Timothy Joseph | en_US |
| dc.date (Date) | 2018 | |
| dc.date.accessioned | 2018-09-11 18:34:10 (UTC+8) | - |
| dc.date.available | 2018-09-11 18:34:10 (UTC+8) | - |
| dc.date.issued (Issue Date) | 2018-09-11 18:34:10 (UTC+8) | - |
| dc.identifier.uri (URI) | http://nccur.lib.nccu.edu.tw/handle/140.119/120071 | - |
| dc.description.abstract (Abstract) | Cerebrospinal fluid (CSF) is a fluidic part of the brain’s microenvironment that isolates the brain from the rest of the body. CSF dilutes metabolites from neuronal activities and removes them from the brain. Its production and resorption are regulated dynamically and are central to maintaining brain homeostasis. We discovered that the major CSF source, the choroid plexus (CP), harbors the brain’s strongest circadian clock. Here, we consider some implications of the CP circadian clock for metabolite clearance in the brain. If the circadian clock contributes to timed production of the CSF, its synchronization with sleep timing can maximize clearance efficiency and help prevent neurodegenerative diseases such as Alzheimer’s disease. | en_US |
| dc.format.extent | 309750 bytes | - |
| dc.format.mimetype | application/pdf | - |
| dc.relation (Relation) | Journal of Experimental Neuroscience, Vol.12 | |
| dc.subject (Keywords) | Choroid plexus; circadian clock; metabolite clearance; neurodegenerative disease | en_US |
| dc.title (Title) | Strong Circadian Rhythms in the Choroid Plexus: Implications for Sleep-Independent Brain Metabolite Clearance | en_US |
| dc.type (Data Type) | article | |
| dc.identifier.doi (DOI) | 10.1177/1179069518783762 | |
| dc.doi.uri | https://doi.org/10.1177/1179069518783762 | |
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