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| Field | Value |
|---|---|
| Title: | Inflow-weighted pulmonary perfusion: Comparison between dynamic contrast-enhanced MRI versus perfusion scintigraphy in complex pulmonary circulation |
| Authors: | 蔡尚岳 Lin,Yi-Ru ; Tsai,Shang-Yueh ;Huang,Teng-Yi ;Chung,Hsiao-Wen ; Huang,Yi-Luan ;Wu,Fu-Zong ;Lin, Chu-Chuan ;Peng, Nan-Jing ;Wu,Ming-Ting |
| Contributors: | 應物所 |
| Keywords: | Pulmonary perfusion; MRI; Pulmonary scintigraphy; Dynamic contrast enhancement-MRI |
| Date: | 2013-03 |
| Issue Date: | 2013-11-27 16:09:18 (UTC+8) |
| Abstract: | Background: Due to the different properties of the contrast agents, the lung perfusion maps as measured by 99mTc-labeled macroaggregated albumin perfusion scintigraphy (PS) are not uncommonly discrepant from those measured by dynamic contrast-enhanced MRI (DCE-MRI) using indicator-dilution analysis in complex pulmonary circulation. Since PS offers the pre-capillary perfusion of the first-pass transit, we hypothesized that an inflow-weighted perfusion model of DCE-MRI could simulate the result by PS. Methods: 22 patients underwent DCE-MRI at 1.5T and also PS. Relative perfusion contributed by the left lung was calculated by PS (PSL%), by DCE-MRI using conventional indicator dilution theory for pulmonary blood volume (PBVL%) and pulmonary blood flow (PBFL%) and using our proposed inflow-weighted pulmonary blood volume (PBViwL%). For PBViwL%, the optimal upper bound of the inflow-weighted integration range was determined by correlation coefficient analysis. Results: The time-to-peak of the normal lung parenchyma was the optimal upper bound in the inflow-weighted perfusion model. Using PSL% as a reference, PBVL% showed error of 49.24% to −40.37% (intraclass correlation coefficient RI = 0.55) and PBFL% had error of 34.87% to −27.76% (RI = 0.80). With the inflow-weighted model, PBViwL% had much less error of 12.28% to −11.20% (RI = 0.98) from PSL%. Conclusions: The inflow-weighted DCE-MRI provides relative perfusion maps similar to that by PS. The discrepancy between conventional indicator-dilution and inflow-weighted analysis represents a mixed-flow component in which pathological flow such as shunting or collaterals might have participated. |
| Relation: | Journal of cardiovascular magnetic resonance ,15(21) |
| Data Type: | article |
| DOI: | http://dx.doi.org/10.1186/1532-429X-15-21 |
| DCField | Value | Language |
|---|---|---|
| dc.contributor (Contributor) | 應物所 | en_US |
| dc.creator (Authors) | 蔡尚岳 | zh_TW |
| dc.creator (Authors) | Lin,Yi-Ru ; Tsai,Shang-Yueh ;Huang,Teng-Yi ;Chung,Hsiao-Wen ; Huang,Yi-Luan ;Wu,Fu-Zong ;Lin, Chu-Chuan ;Peng, Nan-Jing ;Wu,Ming-Ting | en_US |
| dc.date (Date) | 2013-03 | en_US |
| dc.date.accessioned | 2013-11-27 16:09:18 (UTC+8) | - |
| dc.date.available | 2013-11-27 16:09:18 (UTC+8) | - |
| dc.date.issued (Issue Date) | 2013-11-27 16:09:18 (UTC+8) | - |
| dc.identifier.uri (URI) | http://nccur.lib.nccu.edu.tw/handle/140.119/61889 | - |
| dc.description.abstract (Abstract) | Background: Due to the different properties of the contrast agents, the lung perfusion maps as measured by 99mTc-labeled macroaggregated albumin perfusion scintigraphy (PS) are not uncommonly discrepant from those measured by dynamic contrast-enhanced MRI (DCE-MRI) using indicator-dilution analysis in complex pulmonary circulation. Since PS offers the pre-capillary perfusion of the first-pass transit, we hypothesized that an inflow-weighted perfusion model of DCE-MRI could simulate the result by PS. Methods: 22 patients underwent DCE-MRI at 1.5T and also PS. Relative perfusion contributed by the left lung was calculated by PS (PSL%), by DCE-MRI using conventional indicator dilution theory for pulmonary blood volume (PBVL%) and pulmonary blood flow (PBFL%) and using our proposed inflow-weighted pulmonary blood volume (PBViwL%). For PBViwL%, the optimal upper bound of the inflow-weighted integration range was determined by correlation coefficient analysis. Results: The time-to-peak of the normal lung parenchyma was the optimal upper bound in the inflow-weighted perfusion model. Using PSL% as a reference, PBVL% showed error of 49.24% to −40.37% (intraclass correlation coefficient RI = 0.55) and PBFL% had error of 34.87% to −27.76% (RI = 0.80). With the inflow-weighted model, PBViwL% had much less error of 12.28% to −11.20% (RI = 0.98) from PSL%. Conclusions: The inflow-weighted DCE-MRI provides relative perfusion maps similar to that by PS. The discrepancy between conventional indicator-dilution and inflow-weighted analysis represents a mixed-flow component in which pathological flow such as shunting or collaterals might have participated. | - |
| dc.format.extent | 1077979 bytes | - |
| dc.format.mimetype | application/pdf | - |
| dc.language.iso | en_US | - |
| dc.relation (Relation) | Journal of cardiovascular magnetic resonance ,15(21) | en_US |
| dc.subject (Keywords) | Pulmonary perfusion; MRI; Pulmonary scintigraphy; Dynamic contrast enhancement-MRI | en_US |
| dc.title (Title) | Inflow-weighted pulmonary perfusion: Comparison between dynamic contrast-enhanced MRI versus perfusion scintigraphy in complex pulmonary circulation | en_US |
| dc.type (Data Type) | article | en |
| dc.identifier.doi (DOI) | 10.1186/1532-429X-15-21 | en_US |
| dc.doi.uri | http://dx.doi.org/10.1186/1532-429X-15-21 | en_US |
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